Overview

  • Product name

    Recombinant Human ADAMTS18 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      29 kDa
    • Amino acids

      712 to 970
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127804 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    70 % Purified via His tag.
    Purity determined to be 70% by SDS-PAGE.
  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • A disintegrin and metalloproteinase with thrombospondin motifs 18
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 18
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 21
    • ADAM metallopeptidase with thrombospondin type 1 motif 18
    • ADAM-TS 18
    • ADAM-TS18
    • ADAMTS 18
    • ADAMTS-18
    • ADAMTS18
    • ADAMTS21
    • ATS18_HUMAN
    • Disintegrin and metalloprotease like protein
    • EC 3.4.24.
    • KNO2
    see all
  • Tissue specificity

    Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.
  • Sequence similarities

    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 PLAC domain.
    Contains 5 TSP type-1 domains.
  • Domain

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications

    The precursor is cleaved by a furin endopeptidase.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

References

ab127804 has not yet been referenced specifically in any publications.

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