Recombinant Human Aggrecan protein (ab114254)

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Description

  • Product name

    Recombinant Human Aggrecan protein
    See all Aggrecan proteins and peptides

  • Expression system

    Wheat germ

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIP CYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAY QDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVV KGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCD AGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEE MEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAG WLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILT VKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGL GPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQAC LRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKD SSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCES HNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGV RTVYLYPNQTGLPDPLSRHHAFCFRGMQPHFGSNSPFCLERTPLGSPDPA TTQYPIHQSKKMSVPLGQSQL

    • Predicted molecular weight

      105 kDa including tags

    • Amino acids

      1 to 721

Specifications

Our Abpromise guarantee covers the use of ab114254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid

  • Additional notes

     

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • ACAN
    • AGC 1
    • AGC1
    • AGCAN
    • Aggrecan 1
    • Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)
    • Aggrecan core protein
    • Aggrecan proteoglycan
    • Aggrecan structural proteoglycan of cartilage
    • Aggrecan1
    • ATEGQV
    • Cartilage specific proteoglycan core protein
    • Chondroitin sulfate proteoglycan 1
    • Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122
    • Chondroitin sulfate proteoglycan core protein 1
    • CSPG 1
    • CSPG1
    • CSPGCP
    • JSCATE
    • Large aggregating proteoglycan
    • mcspg
    • mgsk16
    • MSK 16
    • MSK16
    • SEDK
    see all

  • Relevance

    Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.

  • Cellular localization

    Secreted; extracellular matrix.

Images

  • SDS-PAGE - Recombinant Human Aggrecan protein (ab114254)
    SDS-PAGE - Recombinant Human Aggrecan protein (ab114254)
    ab114254 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

References

ab114254 has not yet been referenced specifically in any publications.

Publishing research using ab114254? Please let us know so that we can cite the reference in this datasheet.

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