Overview

  • Product name

    Recombinant Human AKAP13/p47 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      18 kDa
    • Amino acids

      2 to 161
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127097 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

     This product was previously labelled as AKAP13

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • A kinase (PRKA) anchor protein 13
    • A kinase anchor protein 13
    • A kinase anchoring protein
    • A-kinase anchor protein 13
    • AKAP 13
    • AKAP Lbc
    • AKAP-13
    • AKAP-Lbc
    • AKAP13
    • AKP13_HUMAN
    • ARHGEF13
    • Breast cancer nuclear receptor binding auxiliary protein
    • Breast cancer nuclear receptor-binding auxiliary protein
    • BRX
    • c lbc
    • FLJ11952
    • FLJ43341
    • Guanine nucleotide exchange factor Lbc
    • HA 3
    • HA3
    • Ht 31
    • Ht31
    • Human thyroid anchoring protein 31
    • Human thyroid-anchoring protein 31
    • LBC
    • LBC oncogene
    • Lymphoid blast crisis oncogene
    • Non oncogenic Rho GTPase specific GTP exchange factor
    • Non-oncogenic Rho GTPase-specific GTP exchange factor
    • p47
    • Protein kinase A anchoring protein 13
    • Protein kinase A-anchoring protein 13
    • PROTO LB
    • PROTO LBC
    see all
  • Function

    Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.
  • Tissue specificity

    Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver, pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver.
  • Sequence similarities

    Contains 1 DH (DBL-homology) domain.
    Contains 1 PH domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
  • Domain

    Both the DH and PH domains are required for transforming activity.
  • Cellular localization

    Cytoplasm; Cytoplasm. Nucleus and Membrane.
  • Information by UniProt

References

ab127097 has not yet been referenced specifically in any publications.

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