Recombinant Human AKR1C4 protein (ab172176)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 0.100 Eu/µg
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Human AKR1C4 protein
See all AKR1C4 proteins and peptides -
Purity
> 95 % SDS-PAGE. -
Endotoxin level
< 0.100 Eu/µg -
Expression system
Escherichia coli -
Accession
-
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MGSSHHHHHHSSGLVPRGSHMDPKYQRVELNDGHFMPVLGFGTYAPPEVP RNRAVEVTKLAIEAG FRHIDSAYLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMV QPALESSLKKLQLDY VDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLA KSIGVSNFNYRQLEM ILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHK LWVDPNSPVLLEDPV LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTS EDMKVLDGLNRNYRY VVMDFLMDHPDYPFSDEY -
Predicted molecular weight
39 kDa including tags -
Amino acids
1 to 323 -
Tags
His tag N-Terminus
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Associated products
-
Related Products
Specifications
Our Abpromise guarantee covers the use of ab172176 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Additional notes
Previously labelled as HSD3a.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.24% Tris, 0.88% Sodium chloride
Supplied as a 0.2 µM filtered solution
General Info
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Alternative names
- 3 alpha HSD1
- 3-alpha-HSD1
- 3-alpha-hydroxysteroid dehydrogenase type I
see all -
Function
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. -
Tissue specificity
Liver specific. -
Sequence similarities
Belongs to the aldo/keto reductase family. -
Post-translational
modificationsThe N-terminus is blocked. -
Cellular localization
Cytoplasm. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab172176 has not yet been referenced specifically in any publications.