Description

  • Product name

    Recombinant Human ALDH6A1 protein
  • Purity

    > 85 % SDS-PAGE.
    ab201884 was purified by using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSSSSVPTV KLFIGGKFVE SKSDKWIDIH NPATNEVIGR VPQATKAEMD AAIASCKRAF PAWADTSVLS RQQVLLRYQQ LIKENLKEIA KLITLEQGKT LADAEGDVFR GLQVVEHACS VTSLMMGETM PSITKDMDLY SYRLPLGVCA GIAPFNFPAM IPLWMFPMAM VCGNTFLMKP SERVPGATML LAKLLQDSGA PDGTLNIIHG QHEAVNFICD HPDIKAISFV GSNKAGEYIF ERGSRHGKRV QANMGAKNHG VVMPDANKEN TLNQLVGAAF GAAGQRCMAL STAVLVGEAK KWLPELVEHA KNLRVNAGDQ PGADLGPLIT PQAKERVCNL IDSGTKEGAS ILLDGRKIKV KGYENGNFVG PTIISNVKPN MTCYKEEIFG PVLVVLETET LDEAIQIVNN NPYGNGTAIF TTNGATARKY AHLVDVGQVG VNVPIPVPLP MFSFTGSRSS FRGDTNFYGK QGIQFYTQLK TITSQWKEED ATLSSPAVVM PTMGR
    • Predicted molecular weight

      57 kDa including tags
    • Amino acids

      34 to 535
    • Tags

      His tag N-Terminus
    • Additional sequence information

      This product is for the mature full length protein from aa 34 to 535. The signal peptide is not included.

Specifications

Our Abpromise guarantee covers the use of ab201884 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituents: 89% PBS, 10% Glycerol, 0.0154% DTT

General Info

  • Alternative names

    • 1110038I05Rik
    • AI314632
    • Aldehyde dehydrogenase 6 family member A1
    • Aldehyde dehydrogenase family 6 member A1
    • Aldehyde dehydrogenase family 6, subfamily A1
    • ALDH6A1
    • Malonate semialdehyde dehydrogenase
    • Malonate-semialdehyde dehydrogenase [acylating]
    • Methylmalonate semialdehyde dehydrogenase [acylating] mitochondrial
    • Methylmalonate-semialdehyde dehydrogenase [acylating]
    • MGC37325
    • MGC40271
    • mitochondrial
    • Mitochondrial acylating methylmalonate semialdehyde dehydrogenase
    • MMSA_HUMAN
    • MMSADHA
    • MMSDH
    see all
  • Function

    Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
  • Involvement in disease

    Defects in ALDH6A1 are the cause of methylmalonate semialdehyde dehydrogenase deficiency (MMSDH deficiency) [MIM:603178]. This is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.
  • Sequence similarities

    Belongs to the aldehyde dehydrogenase family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt

Images

  • 15% SDS PAGE analysis of ab201884 (3 µg).

References

ab201884 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab201884.
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