Overview

  • Product name

    Recombinant Human ALG8 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      9 kDa
    • Amino acids

      26 to 103
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127788 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 95 % Purified via His tag.
    ab127788 is >95% pure by SDS PAGE.
  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute in 250 µl of water.

General Info

  • Alternative names

    • 3-glucosyltransferase
    • AI447372
    • ALG 8
    • alg8
    • ALG8 alpha-1,3-glucosyltransferase
    • ALG8_HUMAN
    • Asparagine linked glycosylation 8 alpha 1,3 glucosyltransferase homolog
    • Asparagine linked glycosylation 8 homolog yeast, alpha 1,3 glucosyltransferase
    • Asparagine linked glycosylation 8 homolog S. cerevisiae, alpha 1,3 glucosyltransferase
    • Asparagine-linked glycosylation protein 8 homolog
    • CDG1H
    • Dolichyl P Glc Glc1Man9GlcNAc2 PP dolichyl glucosyltransferase
    • Dolichyl P glucose Glc1Man9GlcNAc2 PP dolichyl alpha 1,3 glucosyltransferase
    • Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha 1,3 glucosyltransferase
    • Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase
    • Gm1089
    • HUSSY 02
    • MGC2840
    • MGC74399
    • Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha 1,3 glucosyltransferase
    • Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1
    see all
  • Function

    Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.
  • Pathway

    Protein modification; protein glycosylation.
  • Involvement in disease

    Defects in ALG8 are the cause of congenital disorder of glycosylation type 1H (CDG1H) [MIM:608104]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similarities

    Belongs to the ALG6/ALG8 glucosyltransferase family.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt

References

ab127788 has not yet been referenced specifically in any publications.

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