Overview

  • Product name

    Recombinant Human ALKBH4 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      28 kDa
    • Amino acids

      38 to 282
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • 2010004B12Rik
    • ABH4
    • Abj4
    • AlkB, alkylation repair homolog 4 (E. coli)
    • ALKB4_HUMAN
    • Alkbh4
    • Alkylated DNA repair protein alkB homolog 4
    • Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4
    • FLJ20013
    • Probable alpha-ketoglutarate dependent dioxygenase ABH4
    • RGD1308608
    see all
  • Function

    Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.
  • Tissue specificity

    Widely expressed, with highest expression in pancreas, ovary and spleen.
  • Sequence similarities

    Belongs to the alkB family.
  • Cellular localization

    Cytoplasm. Nucleus. Midbody. Associates with the contractile ring and midbody.
  • Information by UniProt

References

ab127375 has not yet been referenced specifically in any publications.

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