Overview

  • Product name

    Recombinant Human ALKBH8 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      27 kDa
    • Amino acids

      2 to 238
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127259 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • 4930562C03Rik
    • 8030431D03Rik
    • 9430088N01Rik
    • ABH8
    • alkB alkylation repair homolog 8
    • alkB alkylation repair homolog 8 (E. coli)
    • AlkB homologue 8
    • ALKB8_HUMAN
    • ALKBH8
    • Alkylated DNA repair protein alkB homolog 8
    • FLJ38204
    • MGC10235
    • OTTHUMP00000211286
    • OTTHUMP00000211287
    • Probable alpha-ketoglutarate-dependent dioxygenase ABH8
    • RGD1304687
    • S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8
    • tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
    see all
  • Function

    Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
  • Tissue specificity

    Widely expressed, with highest expression in spleen, followed by pancreas and lung.
  • Sequence similarities

    Belongs to the alkB family.
    Contains 1 Fe2OG dioxygenase domain.
    Contains 1 RRM (RNA recognition motif) domain.
  • Cellular localization

    Cytoplasm. Nucleus. Predominantly cytoplasmic.
  • Information by UniProt

References

ab127259 has not yet been referenced specifically in any publications.

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