May contribute to the transparency and refractive index of the lens.
Lens as well as other tissues.
Involvement in disease
Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.
Belongs to the small heat shock protein (HSP20) family.
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
SDS-PAGE - Recombinant Human Alpha B Crystallin protein (ab113180)
SDS-PAGE analysis: Lane 1: MWM, Lane 2: 1μg ab113180, Lane 3: 2μg ab113180, Lane 4: 5μg ab113180.
Western blot - Recombinant Human Alpha B Crystallin protein (ab113180)
Western Blot analysis: Lane 1: MW marker, Lane 2: ab113180, Lane 3: bovine native alpha A Crystallin, Lane 4: bovine native Alpha B crystallin. Left: probed with Alpha B crystallin antibody. Right: probed with alpha A crystallin antibody.
has not yet been referenced specifically in any publications.
Publishing research using ab113180? Please let us know so that we can cite the reference in this datasheet.
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