Recombinant Human Amino-terminal enhancer of split/AES protein (ab104756)

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SDS-PAGE - Recombinant Human Amino-terminal enhancer of split/AES protein (ab104756)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE, MS

    Description

    • Product name

      Recombinant Human Amino-terminal enhancer of split/AES protein

    • Purity

      > 95 % SDS-PAGE.
      ab104756 is purified using conventional chromatography techniques.

    • Expression system

      Escherichia coli

    • Accession

      Q08117

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHHSSGLVPRGSHMMFPQSRHSGSSHLPQQLKFTTSDSCDRIK DEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAE IVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAH QLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDK NGHDGDTHQEDDGEKSD

      • Predicted molecular weight

        24 kDa including tags

      • Amino acids

        1 to 197

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab104756 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Mass Spectrometry

    • Mass spectrometry

      MALDI-TOF

    • Form

      Liquid

    • Additional notes

       This product was previously labelled as Amino-terminal enhancer of split

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.0154% DTT, 0.316% Tris HCl, 20% Glycerol (glycerin, glycerine)

    General Info

    • Alternative names

      • aes
      • Aes 1
      • Aes 2
      • AES_HUMAN
      • Aes1
      • Aes2
      • Amino enhancer of split
      • Amino terminal enhancer of split
      • Amino-terminal enhancer of split
      • Esp 1
      • Esp1
      • Gp130 associated protein GAM
      • Gp130-associated protein GAM
      • GRG
      • GRG 5
      • GRG protein
      • Grg-5
      • GRG5
      • Groucho-related protein 5
      • Protein ESP 1
      • Protein ESP1
      • Protein GRG
      • TLE 5
      • TLE5
      see all

    • Function

      Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.

    • Tissue specificity

      Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

    • Sequence similarities

      Belongs to the WD repeat Groucho/TLE family.

    • Domain

      Lacks the C-terminal WD repeats.

    • Post-translational
      modifications

      Ubiquitinated by XIAP/BIRC4.

    • Cellular localization

      Nucleus.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Amino-terminal enhancer of split/AES protein (ab104756)
      SDS-PAGE - Recombinant Human Amino-terminal enhancer of split/AES protein (ab104756)
      15% SDS-PAGE (3µg).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab104756? Please let us know so that we can cite the reference in this datasheet.

    ab104756 has not yet been referenced specifically in any publications.

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