Recombinant Human Amino-terminal enhancer of split/AES protein (ab104756)

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Description

  • Product name

    Recombinant Human Amino-terminal enhancer of split/AES protein

  • Purity

    > 95 % SDS-PAGE.
    ab104756 is purified using conventional chromatography techniques.

  • Expression system

    Escherichia coli

  • Accession

    Q08117

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMMFPQSRHSGSSHLPQQLKFTTSDSCDRIK DEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAE IVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAH QLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDK NGHDGDTHQEDDGEKSD

    • Predicted molecular weight

      24 kDa including tags

    • Amino acids

      1 to 197

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab104756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF

  • Form

    Liquid

  • Additional notes

     This product was previously labelled as Amino-terminal enhancer of split

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.0154% DTT, 0.316% Tris HCl, 20% Glycerol

General Info

  • Alternative names

    • aes
    • Aes 1
    • Aes 2
    • AES_HUMAN
    • Aes1
    • Aes2
    • Amino enhancer of split
    • Amino terminal enhancer of split
    • Amino-terminal enhancer of split
    • Esp 1
    • Esp1
    • Gp130 associated protein GAM
    • Gp130-associated protein GAM
    • GRG
    • GRG 5
    • GRG protein
    • Grg-5
    • GRG5
    • Groucho-related protein 5
    • Protein ESP 1
    • Protein ESP1
    • Protein GRG
    • TLE 5
    • TLE5
    see all

  • Function

    Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.

  • Tissue specificity

    Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

  • Sequence similarities

    Belongs to the WD repeat Groucho/TLE family.

  • Domain

    Lacks the C-terminal WD repeats.

  • Post-translational
    modifications

    Ubiquitinated by XIAP/BIRC4.

  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Amino-terminal enhancer of split/AES protein (ab104756)
    SDS-PAGE - Recombinant Human Amino-terminal enhancer of split/AES protein (ab104756)
    15% SDS-PAGE (3µg).

References

ab104756 has not yet been referenced specifically in any publications.

Publishing research using ab104756? Please let us know so that we can cite the reference in this datasheet.

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