Overview

  • Product name

    Recombinant Human AMPD3 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      27 kDa
    • Amino acids

      541 to 776
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127490 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • Adenosine monophosphate deaminase (isoform E)
    • Adenosine monophosphate deaminase 3
    • AMP aminohydrolase
    • AMP deaminase 3
    • AMP deaminase isoform E
    • Ampd3
    • AMPD3_HUMAN
    • Erythrocyte AMP deaminase
    • Erythrocyte specific AMP deaminase
    • Erythrocyte specific protein
    • Erythrocyte type AMP deaminase
    • Erythroid Marker
    • Myoadenylate deaminase
    • OTTHUMP00000230743
    • OTTHUMP00000230746
    • OTTHUMP00000230747
    • OTTHUMP00000230748
    • OTTHUMP00000230749
    see all
  • Function

    AMP deaminase plays a critical role in energy metabolism.
  • Tissue specificity

    Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.
  • Pathway

    Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.
  • Involvement in disease

    Defects in AMPD3 are the cause of adenosine monophosphate deaminase deficiency erythrocyte type (AMPDDE) [MIM:612874]; also known as erythrocyte AMP deaminase deficiency. AMPDDE is a metabolic disorder due to lack of activity of the erythrocyte isoform of AMP deaminase. It is a clinically asymptomatic condition characterized by a 50% increase in steady-state levels of ATP in affected cells. Individuals with complete deficiency of erythrocyte AMP deaminase are healthy and have no hematologic disorders.
  • Sequence similarities

    Belongs to the adenosine and AMP deaminases family.
  • Information by UniProt

References

ab127490 has not yet been referenced specifically in any publications.

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