Recombinant Human AMPK alpha 1 protein (ab202156)

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Description

  • Product name

    Recombinant Human AMPK alpha 1 protein
    See all AMPK alpha 1 proteins and peptides

  • Purity

    > 85 % SDS-PAGE.
    ab202156 was purified by conventional chromatography techniques.

  • Expression system

    Escherichia coli

  • Accession

    Q13131

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMGSMRRLSSWRKMATAEKQKHDGRVKIGHY ILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQ NLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKES RRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDD DHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHE WF

    • Predicted molecular weight

      34 kDa including tags

    • Amino acids

      1 to 279

    • Tags

      His tag N-Terminus

    • Additional sequence information

      NP_006242.

Specifications

Our Abpromise guarantee covers the use of ab202156 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8
    Constituents: 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • 5 AMP activated protein kinase alpha 1catalytic subunit
    • 5 AMP activated protein kinase catalytic alpha 1 chain
    • 5' AMP activated protein kinase catalytic subunit alpha 1
    • 5'-AMP-activated protein kinase catalytic subunit alpha-1
    • AAPK1
    • AAPK1_HUMAN
    • ACACA kinase
    • acetyl CoA carboxylase kinase
    • AI194361
    • AI450832
    • AL024255
    • AMP -activate kinase alpha 1 subunit
    • AMP-activate kinase alpha 1 subunit
    • AMP-activated protein kinase, catalytic, alpha -1
    • AMPK
    • AMPK 1
    • AMPK alpha 1
    • AMPK alpha 1 chain
    • AMPK subunit alpha 1
    • AMPK subunit alpha-1
    • AMPK1
    • AMPKa1
    • AMPKalpha1
    • C130083N04Rik
    • cb116
    • EC 2.7.11.1
    • HMG CoA reductase kinase
    • HMGCR kinase
    • hormone sensitive lipase kinase
    • Hydroxymethylglutaryl CoA reductase kinase
    • im:7154392
    • kinase AMPK alpha1
    • MGC33776
    • MGC57364
    • OTTHUMP00000161795
    • OTTHUMP00000161796
    • PRKAA 1
    • PRKAA1
    • Protein kinase AMP activated alpha 1 catalytic subunit
    • SNF1-like protein AMPK
    • SNF1A
    • Tau protein kinase PRKAA1
    • wu:fa94c10
    see all

  • Function

    Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

  • Sequence similarities

    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
    Contains 1 protein kinase domain.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human AMPK alpha 1 protein (ab202156)
    SDS-PAGE - Recombinant Human AMPK alpha 1 protein (ab202156)

    15% SDS-PAGE analysis of ab202156 (3µg).

References

ab202156 has not yet been referenced specifically in any publications.

Publishing research using ab202156? Please let us know so that we can cite the reference in this datasheet.

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