Description

  • Product name

    Recombinant Human Angiogenin protein
    See all Angiogenin proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    Purity of ab151351 is greater than 95%, as determined by SEC-HPLC and reducing SDS-PAGE.
  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGN KRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAG FRNVVVACENGLPVHLDQSIFRRP
    • Predicted molecular weight

      14 kDa
    • Amino acids

      25 to 147

Specifications

Our Abpromise guarantee covers the use of ab151351 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Form

    Lyophilised
  • Additional notes

    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

    pH: 7.40
    Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

  • Reconstitution
    Dissolve the lyophilized protein in 1X PBS.
    It is not recommended to reconstitute to a concentration less than 100 µg/ml.

General Info

  • Alternative names

    • ALS9
    • AMYOTROPHIC LATERAL SCLEROSIS
    • ANG
    • ANG 1
    • ANG I
    • ANG1
    • ANGI
    • ANGI_HUMAN
    • Angiogenin
    • Angiogenin ribonuclease RNase A family, 5
    • Epididymis luminal protein 168
    • HEL168
    • MGC22466
    • MGC71966
    • Ribonuclease 5
    • Ribonuclease RNase A Family 5
    • RNase 5
    • RNASE4
    • RNASE5
    see all
  • Function

    May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
  • Tissue specificity

    Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
  • Involvement in disease

    Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.
  • Sequence similarities

    Belongs to the pancreatic ribonuclease family.
  • Developmental stage

    Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.
  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab151351 has not yet been referenced specifically in any publications.

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