Recombinant Human Angiogenin protein (denatured) (ab177677)

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Description

  • Product name

    Recombinant Human Angiogenin protein (denatured)
    See all Angiogenin proteins and peptides

  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    P03950

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHH SSGLVPRGSH MQDNSRYTHF LTQHYDAKPQ GRDDRYCESI MRRRGLTSPC KDINTFIHGN KRSIKAICEN KNGNPHRENL RISKSSFQVT TCKLHGGSPW PPCQYRATAG FRNVVVACEN GLPVHLDQSI FRRP

    • Predicted molecular weight

      16 kDa including tags

    • Amino acids

      25 to 147

    • Tags

      His tag N-Terminus

    • Additional sequence information

      Mature protein. NP_001136.

Specifications

Our Abpromise guarantee covers the use of ab177677 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

General Info

  • Alternative names

    • ALS9
    • AMYOTROPHIC LATERAL SCLEROSIS
    • ANG
    • ANG 1
    • ANG I
    • ANG1
    • ANGI
    • ANGI_HUMAN
    • Angiogenin
    • Angiogenin ribonuclease RNase A family, 5
    • Epididymis luminal protein 168
    • HEL168
    • MGC22466
    • MGC71966
    • Ribonuclease 5
    • Ribonuclease RNase A Family 5
    • RNase 5
    • RNASE4
    • RNASE5
    see all

  • Function

    May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.

  • Tissue specificity

    Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.

  • Involvement in disease

    Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.

  • Sequence similarities

    Belongs to the pancreatic ribonuclease family.

  • Developmental stage

    Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.

  • Cellular localization

    Secreted.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Angiogenin protein (denatured) (ab177677)
    SDS-PAGE - Recombinant Human Angiogenin protein (denatured) (ab177677)

    15% SDS-PAGE analysis of ab177677 (3μg).

References

ab177677 has not yet been referenced specifically in any publications.

Publishing research using ab177677? Please let us know so that we can cite the reference in this datasheet.

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