The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Angiotensin II receptor type 1
Angiotensin II type-1 receptor
Angiotensin receptor 1
Angiotensin receptor 1B
Type 1 angiotensin II receptor
Type 1B angiotensin II receptor
Type-1 angiotensin II receptor
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Liver, lung, adrenal and adrenocortical adenomas.
Involvement in disease
Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Belongs to the G-protein coupled receptor 1 family.
C-terminal Ser or Thr residues may be phosphorylated.