Description

  • Product name

    Recombinant Human Anterior Gradient 2 protein
  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSM RDT TVKPGAKKDT KDSRPKLPQT LSRGWGDQLI WTQTYEEALY KSKTSNKPLM IIHHLDECPH SQALKKVFAE NKEIQKLAEQ FVLLNLVYET TDKHLSPDGQ YVPRIMFVDP SLTVRADITG RYSNRLYAYE PADTALLLDN MKKALKLLKT EL
    • Amino acids

      21 to 175

Specifications

Our Abpromise guarantee covers the use of ab64013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS, pH 7.4

General Info

  • Alternative names

    • AG 2
    • AG 2 protein
    • AG-2
    • AG2
    • AG2 protein
    • AGR 2
    • AGR2
    • AGR2_HUMAN
    • anterior gradient 2 homolog
    • Anterior gradient 2 homolog (Xenopus laevis)
    • Anterior gradient 2, protein disulphide isomerase family member
    • Anterior gradient 2, Xenopus, homolog of
    • Anterior gradient homolog 2
    • Anterior gradient protein 2 homolog
    • Epididymis secretory protein Li 116
    • GOB 4
    • GOB4
    • HAG 2
    • hAG-2
    • hAG2
    • HAG2/R
    • HEL S 116
    • HPC 8
    • hPC8
    • PDIA17
    • Protein disulfide isomerase family A member 17
    • secreted cement gland homolog
    • Secreted cement gland protein XAG 2 homolog
    • Secreted cement gland protein XAG-2 homolog
    • Secreted cement gland protein XAG2 homolog
    • XAG 2
    • XAG2
    see all
  • Function

    Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.
  • Tissue specificity

    Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.
  • Sequence similarities

    Belongs to the AGR family.
  • Cellular localization

    Secreted. Endoplasmic reticulum.
  • Information by UniProt

Images

  • SDS page analysis of ab64013

References

This product has been referenced in:

  • Arumugam T  et al. New Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice. Mol Cancer Ther 14:941-51 (2015). Read more (PubMed: 25646014) »
See 1 Publication for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Question
Answer

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products. I am sorry this peptide wasshorter than stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with the order number xxxx. To check the status of the order please contact our Customer Service team and reference this number. Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know. I wish you the best of luck with your research.

Read More

Question
Answer

The endotoxin level is above 1.0 EU per 1 ug of protein by LAL method. Exact endotoxin level is unknown.

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up