Description

  • Product name

    Recombinant Human AP2S1 protein
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      17 kDa
    • Amino acids

      2 to 142
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • Adapter-related protein complex 2 sigma subunit
    • Adaptor protein complex AP 2 subunit sigma
    • Adaptor protein complex AP-2 subunit sigma
    • Adaptor protein complex AP2 subunit sigma
    • Adaptor related protein complex 2 sigma 1 subunit
    • AI043088
    • AP 17
    • AP 2 complex subunit sigma 1
    • AP-2 complex subunit sigma
    • AP17
    • AP17 delta
    • AP2 complex subunit sigma 1
    • Ap2s1
    • AP2S1_HUMAN
    • CLAPS 2
    • CLAPS2
    • Clathrin adaptor complex AP2, sigma subunit
    • Clathrin adaptor protein AP17
    • Clathrin assembly protein 2 small chain
    • Clathrin associated/assembly/adaptor protein small 2
    • Clathrin associated/assembly/adaptor protein small 2, 17-KD
    • Clathrin associated/assembly/adaptor protein, small 2 (17kD)
    • Clathrin coat assembly protein AP17
    • Clathrin coat associated protein AP17
    • Clathrin coat-associated protein AP17
    • HA2 17 kDa subunit
    • MGC62945
    • Plasma membrane adaptor AP 2 17 kDa protein
    • Plasma membrane adaptor AP-2 17 kDa protein
    • Plasma membrane adaptor AP2 17 kDa protein
    • Sigma adaptin 3b
    • Sigma2 adaptin
    • Sigma2-adaptin
    see all
  • Function

    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
  • Sequence similarities

    Belongs to the adaptor complexes small subunit family.
  • Cellular localization

    Cell membrane. Membrane > coated pit. AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
  • Information by UniProt

References

ab127625 has not yet been referenced specifically in any publications.

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