Description

  • Product name

    Recombinant Human AP4E1 protein
  • Purity

    > 95 % Purified via His tag.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Amino acids

      951 to 1136

Specifications

Our Abpromise guarantee covers the use of ab127858 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Constituent: 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • Adapter-related protein complex 4 subunit epsilon-1
    • Adaptor related protein complex 4 epsilon 1 subunit
    • Adaptor related protein complex AP 4 epsilon
    • AP-4 adapter complex subunit epsilon
    • AP-4 complex subunit epsilon-1
    • Ap4e1
    • AP4E1_HUMAN
    • CPSQ4
    • Epsilon subunit of AP-4
    • Epsilon-adaptin
    see all
  • Function

    Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
  • Tissue specificity

    Widely expressed.
  • Involvement in disease

    Defects in AP4E1 are the cause of cerebral palsy spastic quadriplegic type 4 (CPSQ4) [MIM:613744]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest motor and posture impairments often associated with epilepsy and disturbances of cognition, behavior, sensation, and communication.
  • Sequence similarities

    Belongs to the adaptor complexes large subunit family.
  • Cellular localization

    Golgi apparatus > trans-Golgi network. Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.
  • Information by UniProt

References

ab127858 has not yet been referenced specifically in any publications.

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