Recombinant Human Apc1 protein (ab163855)

Our Abpromise guarantee covers the use of ab163855 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- ANAPC 1
- Anapc1
- Anaphase promoting complex subunit 1
- anaphase-promoting complex 1 (meiotic checkpoint regulator)
- Anaphase-promoting complex subunit 1
- Apc 1
- APC1
- APC1_HUMAN
- Cyclosome subunit 1
- MCPR
- Meiotic checkpoint regulator
- Mitotic checkpoint regulator
- Protein Tsg 24
- Protein Tsg24
- Testis-specific gene 24 protein
- TSG 24
- TSG24
see all
Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Pathway

Protein modification; protein ubiquitination.
Sequence similarities

Belongs to the APC1 family.
Contains 4 PC repeats.
Post-translational
modifications

Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.
Target information above from: UniProt accession Q9H1A4 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human Apc1 protein (ab163855)

ab163855 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab163855 has not yet been referenced specifically in any publications.

Publishing research using ab163855? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"