Overview

  • Product name

    Recombinant Human APCDD1 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Amino acids

      44 to 261

Specifications

Our Abpromise guarantee covers the use of ab127078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • Adenomatosis polyposis coli down regulated 1
    • Adenomatosis polyposis coli down regulated 1 protein
    • Adenomatosis polyposis coli down-regulated 1 protein
    • APCD1_HUMAN
    • APCDD 1
    • APCDD1
    • B7323
    • DRAPC1
    • FP7019
    • HHS
    • HTS
    • hypoptrichosis simplex
    • Protein APCDD1
    see all
  • Function

    Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
  • Tissue specificity

    Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
  • Involvement in disease

    Defects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
  • Sequence similarities

    Belongs to the APCDD1 family.
  • Post-translational
    modifications

    N-Glycosylated.
  • Cellular localization

    Cell membrane.
  • Information by UniProt

References

ab127078 has not yet been referenced specifically in any publications.

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