Description

  • Product name

    Recombinant Human APOB48R protein
  • Expression system

    Wheat germ
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      RGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGA GETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNRE
    • Amino acids

      71 to 170
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163275 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • apo b-100
    • APOB
    • apoB-48R
    • APOBR
    • APOBR_HUMAN
    • Apolipoprotein B receptor
    • Apolipoprotein B-100 receptor
    • Apolipoprotein B-48 receptor
    • Apolipoprotein B48 receptor
    see all
  • Function

    Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.
  • Tissue specificity

    Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells.
  • Post-translational
    modifications

    There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R).
  • Cellular localization

    Cell membrane. Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.
  • Information by UniProt

Images

  • ab163275 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163275 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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