Recombinant human APRIL/TNFSF13 protein (Active) (ab245783)
Key features and details
- Expression system: Insect cells
- Active: Yes
- Suitable for: Functional Studies, SDS-PAGE, HPLC
Description
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Product name
Recombinant human APRIL/TNFSF13 protein (Active)
See all APRIL/TNFSF13 proteins and peptides -
Biological activity
Determined by its ability to induce NF-κB activation in HEK293-NF-κB reporter cells transfected with BCMA receptor.
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Expression system
Insect cells -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
AVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYG VRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHP DRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL -
Predicted molecular weight
16 kDa -
Amino acids
105 to 250 -
Additional sequence information
Full-length mature chain lacking the pro-peptide.
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab245783 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Functional Studies
SDS-PAGE
HPLC
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 0.16% Sodium phosphate, 2.9% Sodium chloride, 5% Trehalose
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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ReconstitutionReconstitute in water to 0.1 - 0.5 mg/ml.
General Info
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Alternative names
- A proliferation inducing ligand
- A proliferation-inducing ligand
- APRIL
see all -
Function
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. -
Tissue specificity
Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages. -
Sequence similarities
Belongs to the tumor necrosis factor family. -
Post-translational
modificationsThe precursor is cleaved by furin. -
Cellular localization
Secreted. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab245783 has not yet been referenced specifically in any publications.