Recombinant human APRIL/TNFSF13 protein (Active) (ab245783)

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Description

  • Product name

    Recombinant human APRIL/TNFSF13 protein (Active)
    See all APRIL/TNFSF13 proteins and peptides

  • Biological activity

    Determined by its ability to induce NF-κB activation in HEK293-NF-κB reporter cells transfected with BCMA receptor.

     

  • Expression system

    Insect cells

  • Accession

    O75888

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      AVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYG VRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHP DRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL

    • Predicted molecular weight

      16 kDa

    • Amino acids

      105 to 250

    • Additional sequence information

      Full-length mature chain lacking the pro-peptide.

Specifications

Our Abpromise guarantee covers the use of ab245783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.5
    Constituents: 0.16% Sodium phosphate, 2.9% Sodium chloride, 5% Trehalose

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute in water to 0.1 - 0.5 mg/ml.

General Info

  • Alternative names

    • A proliferation inducing ligand
    • A proliferation-inducing ligand
    • APRIL
    • CD256
    • TALL-2
    • TALL2
    • TNF related death ligand
    • TNF- and APOL-related leukocyte expressed ligand 2
    • TNF-related death ligand 1
    • TNF13_HUMAN
    • TNFSF13
    • TRDL-1
    • TRDL1
    • Tumor necrosis factor (ligand) superfamily, member 13
    • Tumor necrosis factor ligand superfamily member 13
    • Tumor necrosis factor like protein ZTNF2
    • Tumor necrosis factor related death ligand 1
    • UNQ383/PRO715
    • ZTNF2
    see all

  • Function

    Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.

  • Tissue specificity

    Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

  • Sequence similarities

    Belongs to the tumor necrosis factor family.

  • Post-translational
    modifications

    The precursor is cleaved by furin.

  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab245783 has not yet been referenced specifically in any publications.

Publishing research using ab245783? Please let us know so that we can cite the reference in this datasheet.

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