Description

  • Product name

    Recombinant Human ARHGAP21 protein
  • Purity

    > 95 % Purified via His tag.
    Purity was determined to be >95% by SDS-PAGE.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      20 kDa
    • Amino acids

      10 to 193
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127652 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • Arhgap21
    • KIAA1424
    • RHG21_HUMAN
    • Rho GTPase-activating protein 10
    • Rho GTPase-activating protein 21
    • Rho-type GTPase-activating protein 21
    see all
  • Function

    Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
  • Tissue specificity

    Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.
  • Sequence similarities

    Contains 1 PDZ (DHR) domain.
    Contains 1 PH domain.
    Contains 1 Rho-GAP domain.
  • Cellular localization

    Golgi apparatus membrane. Cell junction. Cytoplasmic vesicle membrane. Cytoplasm > cytoskeleton. Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
  • Information by UniProt

References

ab127652 has not yet been referenced specifically in any publications.

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