Overview

  • Product name

    Recombinant Human ARHGEF9 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      23 kDa
    • Amino acids

      66 to 255
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127597 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • 9630036L12Rik
    • A230067K14
    • ARHG9_HUMAN
    • Arhgef9
    • Cdc42 guanine nucleotide exchange factor (GEF) 9
    • Collybistin
    • collybistin I
    • EIEE8
    • HPEM 2
    • hPEM-2 collybistin
    • KIAA0424
    • mKIAA0424
    • OTTHUMP00000023424
    • OTTHUMP00000023425
    • OTTHUMP00000023427
    • PEM 2
    • PEM 2 homolog
    • PEM-2 homolog
    • PEM2
    • Rac/Cdc42 guanine nucleotide exchange factor 9
    • Rho guanine nucleotide exchange factor 9
    • RP11 357C3.4
    • RP23 230K20.3
    see all
  • Function

    Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
  • Tissue specificity

    Detected in brain. Detected at low levels in heart.
  • Involvement in disease

    Defects in ARHGEF9 are a cause of startle disease with epilepsy (STHEE) [MIM:300607]; also known as hyperekplexia with epilepsy. Startle disease is a genetically heterogeneous neurologic disorder. STHE is characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.
  • Sequence similarities

    Contains 1 DH (DBL-homology) domain.
    Contains 1 PH domain.
    Contains 1 SH3 domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt

References

ab127597 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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