Recombinant human ATAD2 protein (ab198131)
Key features and details
- Expression system: Escherichia coli
- Purity: >= 95% SDS-PAGE
- Active: Yes
- Tags: GST tag N-Terminus
- Suitable for: Functional Studies, SDS-PAGE
Description
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Product name
Recombinant human ATAD2 protein
See all ATAD2 proteins and peptides -
Biological activity
Assay was performed using an ATAD2 Inhibitor Screening Assay Kit.
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Purity
>= 95 % SDS-PAGE. -
Expression system
Escherichia coli -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLEVLFQGPLGSQEEDTFRELRIFLRNVTHR LAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDY LRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQ LCEEIQESR -
Predicted molecular weight
42 kDa including tags -
Amino acids
981 to 1108 -
Tags
GST tag N-Terminus -
Additional sequence information
Bromodomain; NM_014109.
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Specifications
Our Abpromise guarantee covers the use of ab198131 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Functional Studies
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.71% Tris HCl, 0.72% Sodium chloride, 0.02% Potassium chloride, 10% GlycerolThis product is an active protein and may elicit a biological response in vivo, handle with caution.
General Info
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Alternative names
- AAA nuclear coregulator cancer-associated protein
- AAA nuclear coregulator, cancer-associated
- ANCCA
see all -
Function
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. -
Tissue specificity
Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. -
Sequence similarities
Belongs to the AAA ATPase family.
Contains 1 bromo domain. -
Cellular localization
Nucleus. - Information by UniProt
Images
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Functional Studies - Recombinant human ATAD2 protein (ab198131)
Activity assay using ab198131.
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SDS-PAGE - Recombinant human ATAD2 protein (ab198131)4-20% SDS-PAGE analysis of ab198131 (5µg).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab198131 has not yet been referenced specifically in any publications.
