Recombinant human ATAD2 protein (ab198131)

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Description

  • Product name

    Recombinant human ATAD2 protein
    See all ATAD2 proteins and peptides

  • Biological activity

    Assay was performed using an ATAD2 Inhibitor Screening Assay Kit.

  • Purity

    >= 95 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    Q6PL18

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLEVLFQGPLGSQEEDTFRELRIFLRNVTHR LAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDY LRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQ LCEEIQESR

    • Predicted molecular weight

      42 kDa including tags

    • Amino acids

      981 to 1108

    • Tags

      GST tag N-Terminus

    • Additional sequence information

      Bromodomain; NM_014109.

Specifications

Our Abpromise guarantee covers the use of ab198131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8
    Constituents: 0.71% Tris HCl, 0.72% Sodium chloride, 0.02% Potassium chloride, 10% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • AAA nuclear coregulator cancer-associated protein
    • AAA nuclear coregulator, cancer-associated
    • ANCCA
    • Atad2
    • ATAD2_HUMAN
    • ATPase family AAA domain containing 2
    • ATPase family AAA domain containing protein 2
    • ATPase family AAA domain-containing protein 2
    • CT137
    • DKFZp667N1320
    • L16
    • MGC131938
    • MGC142216
    • MGC29843
    • MGC5254
    • PRO2000
    see all

  • Function

    May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

  • Tissue specificity

    Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.

  • Sequence similarities

    Belongs to the AAA ATPase family.
    Contains 1 bromo domain.

  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • Functional Studies - Recombinant human ATAD2 protein (ab198131)
    Functional Studies - Recombinant human ATAD2 protein (ab198131)

    Activity assay using ab198131.

  • SDS-PAGE - Recombinant human ATAD2 protein (ab198131)
    SDS-PAGE - Recombinant human ATAD2 protein (ab198131)

    4-20% SDS-PAGE analysis of ab198131 (5µg).

References

ab198131 has not yet been referenced specifically in any publications.

Publishing research using ab198131? Please let us know so that we can cite the reference in this datasheet.

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