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Recombinant Human ATF1 protein (ab51448)

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SDS-PAGE - Recombinant Human ATF1 protein (ab51448)

    Key features and details

    • Expression system: Baculovirus infected Sf9 cells
    • Purity: > 75% Densitometry
    • Tags: GST tag N-Terminus
    • Suitable for: SDS-PAGE

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    Description

    • Product name

      Recombinant Human ATF1 protein
    • Purity

      > 75 % Densitometry.
      Affinity purified.
    • Expression system

      Baculovirus infected Sf9 cells
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab51448 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 7.50
      Constituents: 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

    General Info

    • Alternative names

      • Activating transcription factor 1
      • ATF 1
      • atf1
      • ATF1 EWS fusion gene
      • ATF1 FUS fusion gene
      • ATF1_HUMAN
      • cAMP dependent transcription factor 1
      • cAMP-dependent transcription factor ATF-1
      • Cyclic AMP dependent transcription factor ATF 1
      • Cyclic AMP dependent transcription factor ATF1
      • Cyclic AMP-dependent transcription factor ATF-1
      • EWS AFT1
      • FUS ATF 1
      • FUS/ATF 1
      • Protein TREB36
      • RNA binding protein activating transcription factor 1 fusion protein
      • TREB 36
      • TREB36
      • TREB36 protein
      see all
    • Function

      This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes.
    • Involvement in disease

      Defects in ATF1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.
    • Sequence similarities

      Belongs to the bZIP family. ATF subfamily.
      Contains 1 bZIP domain.
      Contains 1 KID (kinase-inducible) domain.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession P18846 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human ATF1 protein (ab51448)
      SDS-PAGE - Recombinant Human ATF1 protein (ab51448)
      Recombinant human ATF1 protein (tagged). Molecular weight 63 kDa.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab51448? Please let us know so that we can cite the reference in this datasheet.

    ab51448 has not yet been referenced specifically in any publications.

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