Description

  • Product name

    Recombinant Human AUH protein
  • Purity

    > 95 % SDS-PAGE.
    ab101821 was purified using conventional chromatography.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHHSSGLVPRGSHMSSEMKTEDELRVRHLEEENRGIVVLGINR AYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKER AKMSSSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDI RVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGK EAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQG MEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE
    • Predicted molecular weight

      31 kDa including tags
    • Amino acids

      68 to 339
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab101821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.0154% DTT, 0.316% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • 3 methylglutaconyl CoA hydratase
    • AU binding protein/enoyl CoA hydratase
    • AU RNA binding protein/enoyl CoA hydratase
    • AU RNA binding protein/enoyl Coenzyme A hydratase
    • AU specific RNA binding
    • AU specific RNA binding enoyl CoA hydratase
    • Methylglutaconyl CoA hydratase
    • Methylglutaconyl CoA hydratase mitochondrial
    • MGA Type I
    see all
  • Relevance

    AUH (3-methylglutaconyl-CoA hydratase) catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA and has very low enoyl-CoA hydratase activity. Deletion or mutation of the AUH gene causes the metabolic disease 3-methylglutaconic aciduria type I (MGA1). MGA type I is characterized by an abnormal organic acid profile in which there is excessive urinary excretion of 3-methylglutaconic acid, 3-methylglutaric acid and 3-hydroxyisovaleric acid. AUH is also an RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs.
  • Cellular localization

    Mitochondrial

Images

  • 15% SDS-PAGE analysis of 3µg ab101821.

References

ab101821 has not yet been referenced specifically in any publications.

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