Overview

  • Product name
    Recombinant Human B4GALT1 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      GRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGASSQ PRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLI EFNMPVDLEL
    • Amino acids
      44 to 153
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 384.Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    • 4-galactosyltransferase 1
    • 4-GalTase 1
    • b4Gal-T1
    • B4galt1
    • B4GT1_HUMAN
    • Beta-1
    • Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
    • Beta4Gal-T1
    • CDG2D
    • GGTB2
    • GT1
    • GTB
    • Lactose synthase A protein
    • N-acetyllactosamine synthase
    • Nal synthase
    • Processed beta-1
    • UDP-Gal:beta-GlcNAc beta-1
    • UDP-galactose:beta-N-acetylglucosamine beta-1
    see all
  • Function
    The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
    The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
  • Tissue specificity
    Ubiquitously expressed, but at very low levels in fetal and adult brain.
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Defects in B4GALT1 are the cause of congenital disorder of glycosylation type 2D (CDG2D) [MIM:607091]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similarities
    Belongs to the glycosyltransferase 7 family.
  • Post-translational
    modifications
    The soluble form derives from the membrane forms by proteolytic processing.
  • Cellular localization
    Golgi apparatus > Golgi stack membrane. Cell membrane. Cell surface. Found in trans cisternae of Golgi; Golgi apparatus > Golgi stack membrane. Found in trans cisternae of Golgi and Secreted. Soluble form found in body fluids.
  • Information by UniProt

Images

  • ab158515 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158515 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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