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    recombinant-human-bace1-protein-fc-chimera-ab168902.pdf

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Recombinant Human BACE1 protein (Fc Chimera) (ab168902)

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SDS-PAGE - Recombinant Human BACE1 protein (Fc Chimera) (ab168902)

    Key features and details

    • Expression system: HEK 293 cells
    • Purity: > 90% SDS-PAGE
    • Endotoxin level: < 1.000 Eu/µg
    • Tags: Fc tag N-Terminus
    • Suitable for: SDS-PAGE

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    Description

    • Product name

      Recombinant Human BACE1 protein (Fc Chimera)
      See all BACE1 proteins and peptides
    • Purity

      > 90 % SDS-PAGE.

    • Endotoxin level

      < 1.000 Eu/µg
    • Expression system

      HEK 293 cells
    • Accession

      P56817
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        TQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKS GQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTY RDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI NGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFP LNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEING QDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDG FWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVE DVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACH VHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMT
      • Predicted molecular weight

        75 kDa including tags
      • Amino acids

        22 to 457
      • Tags

        Fc tag N-Terminus
      • Additional sequence information

        The Human BACE-1 will be further processed into mature form (Glu 46-Thr 457). The protein has a calculated MW of 75.2 kDa (pro-form) and 72.6 kDa (mature-form).

    Specifications

    Our Abpromise guarantee covers the use of ab168902 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Additional notes

      This product is stable after storage at:

      • -20°C to -70°C for 12 months in lyophilized state;
      • -70°C for 3 months under sterile conditions after reconstitution.
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Please see notes section.

      pH: 7.4
      Constituents: 5% Trehalose, 0.75% Glycine, 0.61% Tris

    • Reconstitution
      Reconstitute with sterile deionized water to a concentration of 1 mg/ml.

    General Info

    • Alternative names

      • APP beta secretase
      • Asp 2
      • ASP2
      • Aspartyl protease 2
      • BACE
      • BACE 1
      • BACE1
      • BACE1_HUMAN
      • Beta secretase
      • Beta secretase 1
      • Beta site amyloid beta A4 precursor protein cleaving enzyme
      • Beta site amyloid precursor protein cleaving enzyme
      • Beta site amyloid precursor protein cleaving enzyme 1
      • Beta site APP cleaving enzyme
      • Beta site APP cleaving enzyme 1
      • Beta-secretase 1
      • Beta-site amyloid precursor protein cleaving enzyme 1
      • Beta-site APP cleaving enzyme 1
      • FLJ90568
      • HSPC104
      • Memapsin 2
      • Memapsin-2
      • Memapsin2
      • Membrane associated aspartic protease 2
      • Membrane-associated aspartic protease 2
      • Transmembrane aspartic proteinase Asp2
      see all
    • Function

      Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
    • Tissue specificity

      Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
    • Sequence similarities

      Belongs to the peptidase A1 family.
    • Domain

      The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.
    • Post-translational
      modifications

      Glycosylated.
    • Cellular localization

      Membrane. Golgi apparatus > trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
    • Target information above from: UniProt accession P56817 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human BACE1 protein (Fc Chimera) (ab168902)
      SDS-PAGE - Recombinant Human BACE1 protein (Fc Chimera) (ab168902)

      SDS-PAGE analysis of reduced ab168902 stained overnight with Coomassie Blue. The protein ab168902 migrates as 80-96 kDa due to glycosylation. The purity of the protein is greater than 90%.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab168902? Please let us know so that we can cite the reference in this datasheet.

    ab168902 has not yet been referenced specifically in any publications.

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