Description

  • Product name

    Recombinant Human Baf180 protein
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      34 kDa
    • Amino acids

      53 to 345

Specifications

Our Abpromise guarantee covers the use of ab127126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • BAF180
    • BRG1-associated factor 180
    • CG11375
    • hPB1
    • MGC156155
    • MGC156156
    • OTTHUMP00000202149
    • OTTHUMP00000202150
    • OTTHUMP00000202151
    • OTTHUMP00000202153
    • OTTHUMP00000202163
    • PB1
    • PB1_HUMAN
    • Pbrm1
    • polybromo 1
    • Polybromo-1D
    • Protein polybromo-1
    see all
  • Function

    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Act as a negative regulator of cell proliferation.
  • Tissue specificity

    Widely expressed.
  • Involvement in disease

    Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
  • Sequence similarities

    Contains 2 BAH domains.
    Contains 6 bromo domains.
    Contains 1 HMG box DNA-binding domain.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab127126 has not yet been referenced specifically in any publications.

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