Description

  • Product name

    Recombinant Human BAP1 protein
  • Expression system

    Wheat germ
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLF KWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVL LNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPR HLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDE EWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKV NRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANR APAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNP TPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDD YEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAE KLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIG SAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAV RDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVE KEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACL KEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRR RQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
    • Predicted molecular weight

      107 kDa including tags
    • Amino acids

      1 to 729
    • Tags

      GST tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab152849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • BAP 1
    • Bap1
    • BAP1_HUMAN
    • BRCA 1 associated protein 1
    • BRCA1 associated protein 1
    • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    • BRCA1-associated protein 1
    • Cerebral protein 13
    • Cerebral protein 6
    • DKFZp686N04275
    • FLJ35406
    • FLJ37180
    • HUCEP 13
    • Hucep 6
    • HUCEP13
    • Hucep6
    • KIAA0272
    • TPDS
    • Ubiquitin carboxy terminal hydrolase
    • Ubiquitin carboxyl terminal hydrolase BAP 1
    • Ubiquitin carboxyl terminal hydrolase BAP1
    • Ubiquitin carboxyl-terminal hydrolase BAP1
    • UCHL2
    see all
  • Function

    Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor.
  • Tissue specificity

    Highly expressed in testis, placenta and ovary. Expressed in breast.
  • Sequence similarities

    Belongs to the peptidase C12 family. BAP1 subfamily.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm. Nucleus. Mainly nuclear. Binds to chromatin.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab152849 stained with Coomassie Blue.

References

ab152849 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab152849.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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