Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      13 kDa

Associated products

Specifications

Our Abpromise guarantee covers the use of ab9976 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Form
    Lyophilised
  • Additional notes
    The biological activity of of hBCA-1 was determined by a chemotaxis assay using human B cells. Significant chemotaxis was achieved at a concentration range of 1.0-10.0 ng/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • ANGIE
    • ANGIE2
    • B cell attracting chemokine 1
    • B cell-attracting chemokine 1
    • B lymphocyte chemoattractant
    • B-cell chemoattractant
    • B-cell-attracting chemokine 1
    • B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
    • BCA-1
    • BLC
    • BLR1L
    • C-X-C motif chemokine 13
    • Chemokine (C-X-C motif) ligand 13
    • Chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
    • Chemokine, CXC motif, ligand 13
    • CXC chemokine BLC
    • CXCL13
    • CXL13_HUMAN
    • SCYB13
    • Small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
    • Small inducible cytokine B13
    • Small inducible cytokine subfamily B, member 13
    • Small-inducible cytokine B13
    see all
  • Function
    Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
  • Tissue specificity
    Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.
  • Sequence similarities
    Belongs to the intercrine alpha (chemokine CxC) family.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab9976 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Question

Dr Hugh Spotswood, Technical Support: Welcome to Abcam's live support service. How may I help? Visitor: Hi Visitor: I am interested in your CXCL13 Dr Hugh Spotswood, Technical Support: Great, did you have a particular catalogue product in mind? Visitor: Do you make it (human CXCL13) yourselves or do you purchase it? Visitor: ab9976 Dr Hugh Spotswood, Technical Support: Let me have a look, please give me a minute. Dr Hugh Spotswood, Technical Support: ab9976 is BCA-1 (human) recombinant protein. Is this what you are interested in? Visitor: yes. you list it as recombinant from E. coli. DO you make it yourselves? Dr Hugh Spotswood, Technical Support: We source this product. Dr Hugh Spotswood, Technical Support: What would you like to know about it? Visitor: OK, Do you do the characterization or does the source?> Dr Hugh Spotswood, Technical Support: The characterisation is performed by our source. What information would you like to know with regards its characterisation? Visitor: DO they provide Mass-spec data on the purified product? Dr Hugh Spotswood, Technical Support: I do not know, but I can certainly enquire on your behalf and get back to you by e-mail. Visitor: Thanks. Another question. Do you also source the BCA1 antibody (ab9975) from the same source? Dr Hugh Spotswood, Technical Support: Yes, do you have a question in relation to this antibody Visitor: Nothing now. I would appreciate any information you can find on the BCA-1 you source. We have been comparing from souces and find some differences. Dr Hugh Spotswood, Technical Support: Please can you tell me whether you are referring to the BCA-1 protein or the antibody? Visitor: BCA-1 protein (ab9976) Dr Hugh Spotswood, Technical Support: Yes, certainly. I will log your enquiry and get back to you by e-mail if this is Ok with you. Requested details of ab9976 - Is it characterised by mass spec?

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Answer

Thank you for your enquiry. I have been in touch with the source of this antibody and they have told me that every LOT of BCA1 protein (ab9976) is verified/characterized using mass spec. Should you require specific data for a particular LOT number then this is definitely something that I can arrange. I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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