Description

  • Product name

    Recombinant Human Bcl-XL protein
    See all Bcl-XL proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA AESRKGQERF NR
    • Predicted molecular weight

      24 kDa
    • Amino acids

      1 to 212

Specifications

Our Abpromise guarantee covers the use of ab151924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.37% Potassium chloride, 0.48% HEPES, 20% Glycerol

General Info

  • Alternative names

    • Apoptosis regulator Bcl X
    • Apoptosis regulator Bcl-X
    • Apoptosis regulator BclX
    • B cell lymphoma 2 like
    • B2CL1_HUMAN
    • Bcl 2 like 1 protein
    • Bcl X
    • Bcl xL
    • BCL XL/S
    • Bcl xS
    • Bcl-2-like protein 1
    • Bcl2 Like 1
    • Bcl2 related gene
    • Bcl2-L-1
    • BCL2L
    • Bcl2l1
    • BCLX
    • BclXL
    • BclXs
    • DKFZp781P2092
    • PPP1R52
    • Protein phosphatase 1 regulatory subunit 52
    see all
  • Function

    Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
    Isoform Bcl-X(S) promotes apoptosis.
  • Tissue specificity

    Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
  • Sequence similarities

    Belongs to the Bcl-2 family.
  • Domain

    The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
  • Post-translational
    modifications

    Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
  • Cellular localization

    Mitochondrion membrane. Nucleus membrane. Mitochondrial membranes and perinuclear envelope.
  • Information by UniProt

References

ab151924 has not yet been referenced specifically in any publications.

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