Overview

  • Product name

    Recombinant Human Bcl2L2 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETQLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RT
    • Molecular weight

      19 kDa
    • Amino acids

      1 to 172

Specifications

Our Abpromise guarantee covers the use of ab151806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    SDS-PAGE

  • Endotoxin level

    < 1.000 Eu/µg
  • Purity

    > 95 % SDS-PAGE.
    Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Supplied as a 0.2 µM filtered solution.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.75% Potassium chloride, 0.06% HEPES, 20% Glycerol

General Info

  • Alternative names

    • Apoptosis regulator BCL W
    • Apoptosis regulator Bcl-W
    • B2CL2_HUMAN
    • BCL 2 Like 2
    • Bcl 2 like 2 protein
    • Bcl 2L2
    • BCL W
    • Bcl-2-like protein 2
    • Bcl2 L2
    • BCL2 like 2
    • BCL2 like 2 protein
    • Bcl2-L-2
    • Bcl2l2
    • BCLW
    • KIAA0271
    • PPP1R51
    • Protein phosphatase 1 regulatory subunit 51
    see all
  • Function

    Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
  • Tissue specificity

    Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
  • Sequence similarities

    Belongs to the Bcl-2 family.
  • Domain

    The BH4 motif seems to be involved in the anti-apoptotic function.
    The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.
  • Cellular localization

    Mitochondrion membrane. Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
  • Information by UniProt

References

ab151806 has not yet been referenced specifically in any publications.

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