Recombinant Human beta 2 Microglobulin protein (ab98116)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE, MS
Description
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Product name
Recombinant Human beta 2 Microglobulin protein
See all beta 2 Microglobulin proteins and peptides -
Purity
> 95 % SDS-PAGE.
ab98116 is purified by using conventional chromatography techniques. -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MGSSHHHHHH SSGLVPRGSH MIQRTPKIQV YSRHPAENGK SNFLNCYVSG FHPSDIEVDL LKNGERIEKV EHSDLSFSKD WSFYLLYYTE FTPTEKDEYA CRVNHVTLSQ PKIVKWDRDM -
Predicted molecular weight
14 kDa including tags -
Amino acids
21 to 119 -
Tags
His tag N-Terminus
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Associated products
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Related Products
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Biotin Anti-beta 2 Microglobulin antibody [B2M-01] (ab21899)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)
- Anti-beta 2 Microglobulin antibody (ab6608)
- Anti-beta 2 Microglobulin antibody [EP2978Y] (ab75853)
- Anti-beta 2 Microglobulin antibody [B2M-01] (ab759)
Specifications
Our Abpromise guarantee covers the use of ab98116 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Mass Spectrometry
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Mass spectrometry
MALDI-TOF -
Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 8.00
Constituents: 0.0308% DTT, 0.316% Tris HCl, 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride
General Info
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Alternative names
- B2M
- B2MG_HUMAN
- Beta 2 microglobin
see all -
Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. -
Involvement in disease
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. -
Sequence similarities
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain. -
Post-translational
modificationsGlycation of Ile-21 is observed in long-term hemodialysis patients. -
Cellular localization
Secreted. Detected in serum and urine. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab98116 has been referenced in 3 publications.
- Feng Y et al. METTL3/METTL14 Transactivation and m6A-Dependent TGF-ß1 Translation in Activated Kupffer Cells. Cell Mol Gastroenterol Hepatol 12:839-856 (2021). PubMed: 33992834
- Feng Y et al. GR-mediated transcriptional regulation of m6A metabolic genes contributes to diet-induced fatty liver in hens. J Anim Sci Biotechnol 12:117 (2021). PubMed: 34872591
- Feng Y et al. Chronic corticosterone exposure induces liver inflammation and fibrosis in association with m6A-linked post-transcriptional suppression of heat shock proteins in chicken. Cell Stress Chaperones 25:47-56 (2020). PubMed: 31745845