Recombinant Human beta Synuclein protein (ab140415)

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Description

  • Product name

    Recombinant Human beta Synuclein protein
    See all beta Synuclein proteins and peptides

  • Purity

    > 95 % Densitometry.

  • Expression system

    Escherichia coli

  • Accession

    Q16143

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQ GVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQ EAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA

    • Predicted molecular weight

      19 kDa including tags

    • Amino acids

      1 to 134

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab140415 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 0.002% PMSF, 0.71% Sodium phosphate, 0.004% DTT, 25% Glycerol, 1.75% Sodium chloride

General Info

  • Alternative names

    • 14 kDa brain-specific protein
    • Beta-synuclein
    • Phosphoneuroprotein 14
    • PNP14
    • Sncb
    • Synuclein beta
    • SYUB_HUMAN
    see all

  • Function

    Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

  • Tissue specificity

    Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

  • Sequence similarities

    Belongs to the synuclein family.

  • Post-translational
    modifications

    Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.

  • Cellular localization

    Cytoplasm.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human beta Synuclein protein (ab140415)
    SDS-PAGE - Recombinant Human beta Synuclein protein (ab140415)
    SDS-PAGE analysis of ab140415.

References

ab140415 has not yet been referenced specifically in any publications.

Publishing research using ab140415? Please let us know so that we can cite the reference in this datasheet.

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