Recombinant Human beta Synuclein protein (ab140415)

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SDS-PAGE - Recombinant Human beta Synuclein protein (ab140415)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% Densitometry
    • Tags: His tag N-Terminus
    • Suitable for: WB, SDS-PAGE

    Description

    • Product name

      Recombinant Human beta Synuclein protein
      See all beta Synuclein proteins and peptides

    • Purity

      > 95 % Densitometry.

    • Expression system

      Escherichia coli

    • Accession

      Q16143

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQ GVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQ EAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA

      • Predicted molecular weight

        19 kDa including tags

      • Amino acids

        1 to 134

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab140415 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 7.00
      Preservative: 1.02% Imidazole
      Constituents: 0.002% PMSF, 0.82% Sodium phosphate, 0.004% DTT, 25% Glycerol (glycerin, glycerine), 1.75% Sodium chloride

    General Info

    • Alternative names

      • 14 kDa brain-specific protein
      • Beta-synuclein
      • Phosphoneuroprotein 14
      • PNP14
      • Sncb
      • Synuclein beta
      • SYUB_HUMAN
      see all

    • Function

      Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

    • Tissue specificity

      Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

    • Sequence similarities

      Belongs to the synuclein family.

    • Post-translational
      modifications

      Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.

    • Cellular localization

      Cytoplasm.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human beta Synuclein protein (ab140415)
      SDS-PAGE - Recombinant Human beta Synuclein protein (ab140415)
      SDS-PAGE analysis of ab140415.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab140415? Please let us know so that we can cite the reference in this datasheet.

    ab140415 has not yet been referenced specifically in any publications.

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