Description

  • Product name

    Recombinant Human Bim protein (denatured)
    See all Bim proteins and peptides
  • Purity

    > 80 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMAKQPS DVSSECDREG RQLQPAERPP QLRPGAPTSL QTEPQDRSPA PMSCDKSTQT PSPPCQAFNH YLSAMASMRQ AEPADMRPEI WIAQELRRIG DEFNAYYARR VFLNNYQAAE DHPRMVILRL LRYIVRLVWR MH
    • Predicted molecular weight

      19 kDa including tags
    • Amino acids

      1 to 138
    • Tags

      His tag N-Terminus
  • Description

    Recombinant Human Bim protein

Specifications

Our Abpromise guarantee covers the use of ab130020 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 12.01% Urea, 0.08% DTT, 0.32% Tris HCl, 20% Glycerol, 1.75% Sodium chloride

General Info

  • Alternative names

    • BCL2 like 11
    • B2L11_HUMAN
    • BAM
    • Bcl 2 interacting protein Bim
    • Bcl 2 related ovarian death agonist
    • Bcl-2-like protein 11
    • BCL2 interacting mediator of cell death
    • BCL2 like 11 (apoptosis facilitator)
    • BCL2 like protein 11
    • Bcl2-interacting mediator of cell death
    • Bcl2-L-11
    • Bcl2l11
    • BIM
    • BIM alpha6
    • BIM beta6
    • BIM beta7
    • BimEL
    • BimL
    • BOD
    see all
  • Function

    Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
  • Tissue specificity

    Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
  • Sequence similarities

    Belongs to the Bcl-2 family.
  • Domain

    The BH3 motif is required for Bcl-2 binding and cytotoxicity.
  • Cellular localization

    Mitochondrion and Endomembrane system. Associated with intracytoplasmic membranes.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab130020 (3 µg).

References

ab130020 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab130020.
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