• Nature
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
    • Amino acids
      293 to 408

Associated products


Our Abpromise guarantee covers the use of ab51998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    The ED50 as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12μg/ml.

  • Applications


  • Purity
    > 95 % SDS-PAGE.
    Sterile filtered. Endotoxin level is < 0.1 ng per µg of BMP4.
  • Form
  • Additional notes
    The lyophilized protein is best-stored desiccated below 0oC. Reconstituted BMP-4 should be stored in working aliquots at -20oC. For long-term storage, it is recommended to add a carrier protein (0.1% BSA). Following reconstitution, this solution can be diluted into other aqueous buffers and stored at 4oC for 1 week or –20oC for future use.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Centrifuge the vial prior to opening. Reconstitute to a concentration of 0.1 - 1.0 mg/ml in water.

General Info

  • Alternative names
    • zgc:100779
    • BMP 2B
    • BMP 4
    • BMP-2B
    • BMP-4
    • BMP2B
    • BMP2B1
    • BMP4
    • BMP4_HUMAN
    • Bone morphogenetic protein 2B
    • Bone morphogenetic protein 4
    • DVR4
    • MCOPS6
    • MGC100779
    • OFC11
    • zbmp-4
    • ZYME
    see all
  • Function
    Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
  • Tissue specificity
    Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
  • Involvement in disease
    Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [MIM:607932]; also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies.
    Defects in BMP4 are the cause of non-syndromic orofacial cleft type 11 (OFC11) [MIM:600625]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC11 is an unusual anomaly consisting of a paramedian scar of the upper lip with an appearance suggesting that a typical cleft lip was corrected in utero.
  • Sequence similarities
    Belongs to the TGF-beta family.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt


ab51998 has not yet been referenced specifically in any publications.

Customer reviews and Q&As


Thank you for contacting us and your interest in our products.

We currently have three human BMP4 protein products available.

https://www.abcam.com/BMP4-protein-MBP-ab92855.htmlRecombinant full length protein, corresponding to amino acids 25-408 of Human BMP4 with His-MBP tag expressed in E coli.

https://www.abcam.com/BMP4-protein-Human-ab87063.htmlRecombinant full length mature form Human BMP4, amino acids 293-408 also expressed in E. coli


https://www.abcam.com/BMP4-protein-ab51998.htmlRecombinant full length protein, corresponding to amino acids 293-408 of Human BMP4 E.coli.

The only protein for which I have any data currently to show the protein has biological activity is ab51998. This was shown to produce a dose-dependentinduction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 µg/ml. This protein is currently not in stock but if ordered today would reach you by the 21st of February.

Once I have further information on how the proteins have been used I will get back to you with this.

I hope in the meantime this information has been of help.

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