Recombinant Human BMPER protein (ab165805)

Product name

Recombinant Human BMPER protein
Protein length

Full length protein

Nature

Recombinant
Source

Wheat germ
Amino Acid Sequence
- Species
  
  Human
- Sequence
  
  MLWFSGVGALAERYCRRSPGITCCVLLLLNCSGVPMSLASSFLTGSVAKC ENEGEVLQIPFITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGA CCEQCKGCTYEGNTYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCVVHCK NPLEHLGMCCPTCPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVR EVCPILSCPQHLSHIPPGQCCPKCLGQRKVFDLPFGSCLFRSDVYDNGSS FLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQEGCCEECLLRVPPEDIKV CKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKILNR KGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASP FQVLVKNDARRTRSFSWTKSVELVLGESRVSLQQHLTVRWNGSRIALPCR APHFHIDLDGYLLKVTTKAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNY NGHKRDDLIGGDGNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQGTV KVKLRAHRECQKLKSWEFQTCHSTVDYATFYRSCVTDMCECPVHKNCYCE SFLAYTRACQREGIKVHWEPQQNCAATQCKHGAVYDTCGPGCIKTCDNWN EIGPCNKPCVAGCHCPANLVLHKGRCIKPVLCPQR
- Amino acids
  
  1 to 685
- Tags
  
  proprietary tag N-Terminus

Our Abpromise guarantee covers the use of ab165805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

ELISA

Western blot
Form

Liquid
Additional notes

Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...

Stability and Storage

Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl

Alternative names
- BMP binding endothelial regulator
- BMP binding endothelial regulator precursor protein
- BMP-binding endothelial regulator protein
- BMPER
- BMPER_HUMAN
- Bone morphogenetic protein binding endothelial cell precursor derived regulator
- Bone morphogenetic protein-binding endothelial cell precursor-derived regulator
- CRIM3
- Crossveinless 2
- CV 2
- CV2
- hCV2
- Protein crossveinless 2
- Protein crossveinless-2
see all
Function

Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
Tissue specificity

Highly expressed in lung, and brain and also in primary chondrocytes.
Involvement in disease

Defects in BMPER are the cause of diaphanospondylodysostosis (DSD) [MIM:608022]. A rare, recessively inherited, perinatal lethal skeletal disorder. The primary skeletal characteristics of the phenotype include a small chest, abnormal vertebral segmentation, and posterior rib gaps containing incompletely differentiated mesenchymal tissue. Consistent craniofacial features include ocular hypertelorism, epicanthal folds, a depressed nasal bridge with a short nose, and low-set ears. The most commonly described extraskeletal finding is nephroblastomatosis with cystic kidneys, but other visceral findings have been described in some cases.
Sequence similarities

Contains 1 TIL (trypsin inhibitory-like) domain.
Contains 5 VWFC domains.
Contains 1 VWFD domain.
Cellular localization

Secreted.
Target information above from: UniProt accession Q8N8U9 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human BMPER protein (ab165805)

ab165805 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Datasheet

ab165805 has not yet been referenced specifically in any publications.

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Recombinant Human BMPER protein (ab165805)

Overview

Description

Specifications

Preparation and Storage

General Info

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References

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