Recombinant Human BMPER protein (ab165805)

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SDS-PAGE - Recombinant Human BMPER protein (ab165805)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human BMPER protein

    • Expression system

      Wheat germ

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MLWFSGVGALAERYCRRSPGITCCVLLLLNCSGVPMSLASSFLTGSVAKC ENEGEVLQIPFITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGA CCEQCKGCTYEGNTYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCVVHCK NPLEHLGMCCPTCPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVR EVCPILSCPQHLSHIPPGQCCPKCLGQRKVFDLPFGSCLFRSDVYDNGSS FLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQEGCCEECLLRVPPEDIKV CKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKILNR KGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASP FQVLVKNDARRTRSFSWTKSVELVLGESRVSLQQHLTVRWNGSRIALPCR APHFHIDLDGYLLKVTTKAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNY NGHKRDDLIGGDGNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQGTV KVKLRAHRECQKLKSWEFQTCHSTVDYATFYRSCVTDMCECPVHKNCYCE SFLAYTRACQREGIKVHWEPQQNCAATQCKHGAVYDTCGPGCIKTCDNWN EIGPCNKPCVAGCHCPANLVLHKGRCIKPVLCPQR

      • Amino acids

        1 to 685

      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab165805 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid

    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • BMP binding endothelial regulator
      • BMP binding endothelial regulator precursor protein
      • BMP-binding endothelial regulator protein
      • BMPER
      • BMPER_HUMAN
      • Bone morphogenetic protein binding endothelial cell precursor derived regulator
      • Bone morphogenetic protein-binding endothelial cell precursor-derived regulator
      • CRIM3
      • Crossveinless 2
      • CV 2
      • CV2
      • hCV2
      • Protein crossveinless 2
      • Protein crossveinless-2
      see all

    • Function

      Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.

    • Tissue specificity

      Highly expressed in lung, and brain and also in primary chondrocytes.

    • Involvement in disease

      Defects in BMPER are the cause of diaphanospondylodysostosis (DSD) [MIM:608022]. A rare, recessively inherited, perinatal lethal skeletal disorder. The primary skeletal characteristics of the phenotype include a small chest, abnormal vertebral segmentation, and posterior rib gaps containing incompletely differentiated mesenchymal tissue. Consistent craniofacial features include ocular hypertelorism, epicanthal folds, a depressed nasal bridge with a short nose, and low-set ears. The most commonly described extraskeletal finding is nephroblastomatosis with cystic kidneys, but other visceral findings have been described in some cases.

    • Sequence similarities

      Contains 1 TIL (trypsin inhibitory-like) domain.
      Contains 5 VWFC domains.
      Contains 1 VWFD domain.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human BMPER protein (ab165805)
      SDS-PAGE - Recombinant Human BMPER protein (ab165805)
      ab165805 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab165805? Please let us know so that we can cite the reference in this datasheet.

    ab165805 has not yet been referenced specifically in any publications.

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