Description

  • Product name

    Recombinant human BMPR1A protein
    See all BMPR1A proteins and peptides
  • Biological activity

    The Specific activity of ab105907 was determined to be 1.2 nmol/min/mg.
  • Purity

    > 90 % Densitometry.
    Purity was determined to be >90% by densitometry.
  • Expression system

    Baculovirus infected Sf9 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      66 kDa including tags
    • Amino acids

      187 to 532

Associated products

Specifications

Our Abpromise guarantee covers the use of ab105907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Functional Studies

  • Form

    Liquid
  • Additional notes

    ab204884 (Smad3 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.307% Glutathione, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • 10q23del
    • Activin A receptor type II like kinase 3
    • Activin receptor like kinase 3
    • Activin receptor-like kinase 3
    • ACVRLK 3
    • ACVRLK3
    • ALK 3
    • ALK-3
    • ALK3
    • BMP type-1A receptor
    • Bmpr
    • BMPR 1A
    • BMPR-1A
    • Bmpr1a
    • BMR1A_HUMAN
    • Bone morphogenetic protein receptor type IA
    • Bone morphogenetic protein receptor type IA precursor
    • Bone morphogenetic protein receptor type-1A
    • BR 1a
    • BR1a
    • CD 292
    • CD292
    • CD292 antigen
    • EC 2.7.11.30
    • Serine threonine protein kinase receptor R5
    • Serine threonine protein kinase receptor R5 precursor
    • Serine/threonine-protein kinase receptor R5
    • SKR 5
    • SKR5
    • zBMPR IA
    • zBMPRIA
    see all
  • Function

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
  • Tissue specificity

    Highly expressed in skeletal muscle.
  • Involvement in disease

    Juvenile polyposis syndrome
    Polyposis syndrome, mixed hereditary 2
    A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome.
  • Sequence similarities

    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • The specific activity of BMPR1A (ab105907) was determined to be 1.4 nmol/min/mg as per activity assay protocol
  • SDS PAGE analysis of ab105907
  • SDS PAGE analysis of ab105907
  • Kinase Assay demonstrating specific activity of ab105907 at 1.2 nmol/min/mg.
  • SDS-PAGE showing ab105907 at approximately 66kDa.

References

ab105907 has not yet been referenced specifically in any publications.

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