• Product name

    Recombinant human BMPR1A protein
    See all BMPR1A proteins and peptides
  • Biological activity

    Measured by its ability to inhibit recombinant Human BMP2 induced alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 1-3 µg/ml in the presence of 500 ng/ml of recombinant Human BMP2.
  • Purity

    > 90 % SDS-PAGE.
    ab123844 is purified by proprietary chromatographic techniques. Purity is greater than 90% as determined by HPLC and SDS-PAGE.
  • Expression system

    Baculovirus infected insect cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

  • Nature

    • Species

    • Predicted molecular weight

      23 kDa including tags
    • Tags

      His tag C-Terminus


Our Abpromise guarantee covers the use of ab123844 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


    Functional Studies


  • Form

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    Constituent: 99% PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration of 100 µg/ml. This solution can then be diluted into other aqueous buffers. Reconstituted ab123844 should be stored at 4°C for 2-7 days and at -20°C for future use. For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA) and store as working aliquots at -20°C.

General Info

  • Alternative names

    • 10q23del
    • Activin A receptor type II like kinase 3
    • Activin receptor like kinase 3
    • Activin receptor-like kinase 3
    • ACVRLK 3
    • ACVRLK3
    • ALK 3
    • ALK-3
    • ALK3
    • BMP type-1A receptor
    • Bmpr
    • BMPR 1A
    • BMPR-1A
    • Bmpr1a
    • Bone morphogenetic protein receptor type IA
    • Bone morphogenetic protein receptor type IA precursor
    • Bone morphogenetic protein receptor type-1A
    • BR 1a
    • BR1a
    • CD 292
    • CD292
    • CD292 antigen
    • EC
    • Serine threonine protein kinase receptor R5
    • Serine threonine protein kinase receptor R5 precursor
    • Serine/threonine-protein kinase receptor R5
    • SKR 5
    • SKR5
    • zBMPR IA
    • zBMPRIA
    see all
  • Function

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
  • Tissue specificity

    Highly expressed in skeletal muscle.
  • Involvement in disease

    Juvenile polyposis syndrome
    Polyposis syndrome, mixed hereditary 2
    A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome.
  • Sequence similarities

    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localization

  • Information by UniProt


ab123844 has not yet been referenced specifically in any publications.

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