Description

  • Product name

    Recombinant Human BRDT protein
    See all BRDT proteins and peptides
  • Purity

    >= 98 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      SQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGL HNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDH EVVTMARMLQDVFETHFSKI PIEPVE
    • Predicted molecular weight

      15 kDa including tags
    • Amino acids

      257 to 382
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab176961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • BRD 6
    • BRD6
    • Brdt
    • BRDT protein
    • BRDT_HUMAN
    • Bromodomain testis specific
    • Bromodomain testis specific protein
    • Bromodomain testis-specific protein
    • Cancer/testis antigen 9
    • CT9
    • RING3 like protein
    • RING3-like protein
    • Testis specific bromodomain protein
    see all
  • Function

    May play a role in the transcriptional regulation of spermatogenesis. Seems to have a structural ATP-independent role in the reorganization of acetylated chromatin.
  • Tissue specificity

    Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder.
  • Sequence similarities

    Contains 2 bromo domains.
  • Developmental stage

    Expressed in embryo testis.
  • Domain

    The two bromodomains are involved in the specific recognition of histone H4 acetylated N-terminus.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab176961.

    Lane 1: Markers:
    Lane 2: ab176961 (10 μg)
    Lane 3: ab176961 (25 μg)
    Lane 4: ab176961 (50 μg)

References

ab176961 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab176961.
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