Overview

  • Product name

    Recombinant Human BRI3 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      16 kDa
    • Amino acids

      92 to 227

Specifications

Our Abpromise guarantee covers the use of ab127085 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

    Protein previously labeled as ITM2C.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • BRI3
    • BRICD2C
    • BRICHOS domain containing 2C
    • Cerebral protein 14
    • CT-BRI3
    • E25
    • E25C
    • Integral membrane protein 2C
    • Integral membrane protein 3
    • Itm2c
    • ITM2C_HUMAN
    • ITM3
    • NPD018
    • Transmembrane protein BRI3
    see all
  • Function

    Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
  • Tissue specificity

    High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.
  • Sequence similarities

    Belongs to the ITM2 family.
    Contains 1 BRICHOS domain.
  • Post-translational
    modifications

    Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C.
  • Cellular localization

    Lysosome membrane.
  • Information by UniProt

References

ab127085 has not yet been referenced specifically in any publications.

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