Recombinant Human C11orf79 protein (ab139611)

Overview

  • Product name

    Recombinant Human C11orf79 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSSFRRFYR GDSPTDSQKD MIEIPLPPWQ ERTDESIETK RARLLYESRK RGMLENCILL SLFAKEHLQH MTEKQLNLYD RLINEPSNDW DIYYWATEAK PAPEIFENEV MALLRDFAKN KNKEQRLRAP DLEYLFEKPR
    • Molecular weight

      19 kDa including tags
    • Amino acids

      30 to 166
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab139611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 90 % SDS-PAGE.
    ab139611 is purified using conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 30% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names

    • Chromosome 11 open reading frame 79
    • FLJ20487
    • hSDH5
    • mitochondrial
    • Paraganglioma or familial glomus tumors 2
    • PGL2
    • SDH assembly factor 2
    • SDH5
    • Sdhaf2
    • SDHF2_HUMAN
    • Succinate dehydrogenase assembly factor 2, mitochondrial
    • Succinate dehydrogenase subunit 5
    see all
  • Function

    Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation that is susceptible to autocatalytic FAD attachment.
  • Involvement in disease

    Defects in SDHAF2 are the cause of hereditary paragangliomas type 2 (PGL2) [MIM:601650]; also known as familial non-chromaffin paragangliomas type 2. Paragangliomas refer to rare and mostly benign tumors that arise from any component of the neuroendocrine system. PGL2 is characterized by the development of non-chromaffin paragangliomas of the head and neck. There is a fairly equal distribution of different locations in the head and neck, with the most common location at the carotid body, and a tendency toward tumor multiplicity.
  • Sequence similarities

    Belongs to the SDHAF2 family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab139611 (3µg).

References

ab139611 has not yet been referenced specifically in any publications.

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