Recombinant Human C11orf79 protein (ab139611)
- Datasheet
- References
- Protocols
Description
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Product name
Recombinant Human C11orf79 protein -
Purity
> 90 % SDS-PAGE.
ab139611 is purified using conventional chromatography techniques. -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MGSSHHHHHH SSGLVPRGSH MGSSFRRFYR GDSPTDSQKD MIEIPLPPWQ ERTDESIETK RARLLYESRK RGMLENCILL SLFAKEHLQH MTEKQLNLYD RLINEPSNDW DIYYWATEAK PAPEIFENEV MALLRDFAKN KNKEQRLRAP DLEYLFEKPR -
Predicted molecular weight
19 kDa including tags -
Amino acids
30 to 166 -
Tags
His tag N-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab139611 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Mass Spectrometry
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Mass spectrometry
MALDI-TOF -
Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 8.00
Constituents: 0.02% DTT, 0.32% Tris HCl, 30% Glycerol, 1.17% Sodium chloride
General Info
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Alternative names
- Chromosome 11 open reading frame 79
- FLJ20487
- hSDH5
see all -
Function
Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation that is susceptible to autocatalytic FAD attachment. -
Involvement in disease
Defects in SDHAF2 are the cause of hereditary paragangliomas type 2 (PGL2) [MIM:601650]; also known as familial non-chromaffin paragangliomas type 2. Paragangliomas refer to rare and mostly benign tumors that arise from any component of the neuroendocrine system. PGL2 is characterized by the development of non-chromaffin paragangliomas of the head and neck. There is a fairly equal distribution of different locations in the head and neck, with the most common location at the carotid body, and a tendency toward tumor multiplicity. -
Sequence similarities
Belongs to the SDHAF2 family. -
Cellular localization
Mitochondrion. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human C11orf79 protein (ab139611)15% SDS-PAGE analysis of ab139611 (3µg).
Datasheets and documents
References
ab139611 has not yet been referenced specifically in any publications.
