Overview

  • Product name

    Recombinant Human C1orf19 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MEERGDSEPT PGCSGLGPDG VRGFGDGGGA PSWAPEDAWM GTHPKYLEMM ELDIGDATHV YVAFLVYLDL MESKSWHEVN CVGLPELQLI CLVGTEIEGE GLQTVVPTPI TASLSHNRIR EILKASRKLQ GDPDLPMSFT LAIVESDSTI VYYKLTDGFM LPDPQNISLR R
    • Molecular weight

      21 kDa including tags
    • Amino acids

      1 to 171
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab124991 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 90 % SDS-PAGE.
    ab124991 is purified by proprietary chromatographic techniques.
  • Form

    Liquid
  • Additional notes

    b124991 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    pH: 8.00
    Constituents: 0.03% DTT, 0.32% Tris HCl, 20% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names

    • Chromosome 1 open reading frame 19
    • Chromosome 1 open reading frame 19, isoform CRA_c
    • HsSen15
    • sen15
    • SEN15 homolog
    • SEN15_HUMAN
    • tRNA intron endonuclease Sen15
    • tRNA splicing endonuclease 15 homolog (S. cerevisiae)
    • tRNA splicing endonuclease subunit Sen15
    • tRNA-intron endonuclease SEN15
    • tRNA-splicing endonuclease subunit SEN15
    • Tsen15
    see all
  • Function

    Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3' end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
  • Tissue specificity

    Widely expressed. Highly expressed in testis and uterus.
  • Sequence similarities

    Belongs to the SEN15 family.
  • Cellular localization

    Nucleus. Nucleus > nucleolus. May be transiently localized in the nucleolus.
  • Information by UniProt

References

ab124991 has not yet been referenced specifically in any publications.

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