Recombinant Human Carbonic Anhydrase 12/CA12 protein (ab201875)

Overview

Description

  • Nature

    Recombinant
  • Source

    Insect cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      APVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPL EFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGN PNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLI EMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGS LTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNF RQVQKFDERLVYTSFSQVQVCTAAGLSHHHHHH
    • Molecular weight

      32 kDa including tags
    • Amino acids

      25 to 301
    • Tags

      His tag C-Terminus
    • Additional sequence information

      Extracellular domain (NP_001209).

Specifications

Our Abpromise guarantee covers the use of ab201875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level

    < 1.000 Eu/µg
  • Purity

    > 90 % SDS-PAGE.
    ab201875 was purified by conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituents: 10% Glycerol, 90% PBS

General Info

  • Alternative names

    • CA 12
    • CA XII
    • CA-XII
    • CA12
    • CAH12_HUMAN
    • Carbonate dehydratase XII
    • Carbonic anhydrase 12
    • Carbonic anhydrase XII
    • Carbonic dehydratase
    • CAXII
    • FLJ20151
    • HsT18816
    • T18816
    • Tumor antigen HOM RCC 3.1.3
    • Tumor antigen HOM-RCC-3.1.3
    see all
  • Function

    Reversible hydration of carbon dioxide.
  • Tissue specificity

    Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis.
  • Involvement in disease

    Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:143860]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.
  • Sequence similarities

    Belongs to the alpha-carbonic anhydrase family.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE  analysis of ab201875 (3 µg).

References

ab201875 has not yet been referenced specifically in any publications.

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