Recombinant Human Carbonic Anhydrase 12/CA12 protein (His tag) (ab240768)

Description

  • Product name

    Recombinant Human Carbonic Anhydrase 12/CA12 protein (His tag)
    See all Carbonic Anhydrase 12/CA12 proteins and peptides
  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Yeast
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      APVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPL EFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGN PNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLI EMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGS LTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNF RQVQKFDERLVYTSFSQVQVCTAAGLS
    • Predicted molecular weight

      33 kDa including tags
    • Amino acids

      25 to 301
    • Tags

      His tag N-Terminus
    • Additional sequence information

      N-terminal 6xHis-tagged.

Specifications

Our Abpromise guarantee covers the use of ab240768 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    LC-MS/MS
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Constituents: Tris buffer, 50% Glycerol

General Info

  • Alternative names

    • CA 12
    • CA XII
    • CA-XII
    • CA12
    • CAH12_HUMAN
    • Carbonate dehydratase XII
    • Carbonic anhydrase 12
    • Carbonic anhydrase XII
    • Carbonic dehydratase
    • CAXII
    • FLJ20151
    • HsT18816
    • T18816
    • Tumor antigen HOM RCC 3.1.3
    • Tumor antigen HOM-RCC-3.1.3
    see all
  • Function

    Reversible hydration of carbon dioxide.
  • Tissue specificity

    Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis.
  • Involvement in disease

    Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:143860]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.
  • Sequence similarities

    Belongs to the alpha-carbonic anhydrase family.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • ab240768 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of ab240768 could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) CA12.

  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of ab240768 could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) CA12.

References

ab240768 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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