Recombinant human Carbonic Anhydrase 8/CA8 protein (ab208301)

Description

  • Product name

    Recombinant human Carbonic Anhydrase 8/CA8 protein
  • Biological activity

    Specific activity is > 450 pmol/min/μg, and is defined as the amount of enzyme that hydrolyze 1.0 pmole of 4-nitrophenyl acetate to 4-nitrophenol per minute at pH 7.5 at 37C.

  • Purity

    > 90 % SDS-PAGE.
    ab208301 was purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMADLSF IEDTVAFPEK EEDEEEEEEG VEWGYEEGVE WGLVFPDANG EYQSPINLNS REARYDPSLL DVRLSPNYVV CRDCEVTNDG HTIQVILKSK SVLSGGPLPQ GHEFELYEVR FHWGRENQRG SEHTVNFKAF PMELHLIHWN STLFGSIDEA VGKPHGIAII ALFVQIGKEH VGLKAVTEIL QDIQYKGKSK TIPCFNPNTL LPDPLLRDYW VYEGSLTIPP CSEGVTWILF RYPLTISQLQ IEEFRRLRTH VKGAELVEGC DGILGDNFRP TQPLSDRVIR AAFQ
    • Predicted molecular weight

      36 kDa including tags
    • Amino acids

      1 to 290
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NP_004047.

Specifications

Our Abpromise guarantee covers the use of ab208301 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

    Functional Studies

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol, 0.02% DTT

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • CA VIII
    • CA-VIII
    • Ca8
    • CAH8_HUMAN
    • CALS
    • Carbonic anhydrase related protein
    • Carbonic anhydrase VIII
    • Carbonic anhydrase-related protein
    • CARP
    • MGC120502
    • MGC99509
    see all
  • Function

    Does not have a carbonic anhydrase catalytic activity.
  • Involvement in disease

    Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3) [MIM:613227]. CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.
  • Sequence similarities

    Belongs to the alpha-carbonic anhydrase family.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab208301 (3μg).

References

ab208301 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab208301.
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