Description

  • Product name

    Recombinant human Casein Kinase 1 delta/CSNK1D protein
    See all Casein Kinase 1 delta/CSNK1D proteins and peptides
  • Biological activity

    The Specific activity of ab103955 was determined to be 82 nmol/min/mg.
  • Purity

    > 80 % Densitometry.
    Purity was determined to be >80% by densitometry.
  • Expression system

    Baculovirus infected Sf9 cells
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      72 kDa including tags
    • Amino acids

      1 to 415

Specifications

Our Abpromise guarantee covers the use of ab103955 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Additional notes

    ab91090 (Cow Casein full length protein) can be utilized as a substrate for assessing Kinase activity

    Previously labelled as Casein Kinase 1 delta. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.307% Glutathione, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • Casein Kinase 1 delta
    • Casein kinase I delta isoform
    • Casein kinase I isoform delta
    • CKI delta
    • CKI-delta
    • CKId
    • CKIdelta
    • CSNK 1D
    • CSNK1D
    • HCKID
    • KC1D_HUMAN
    • Protein kinase CK1 delta
    see all
  • Function

    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
  • Tissue specificity

    Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
  • Involvement in disease

    Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Autophosphorylated on serine and threonine residues.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt

Images

  • The specific activity of Casein Kinase 1 delta/CSNK1D (ab103955) was determined to be 77 nmol/min/mg as per activity assay protocol
  • SDS PAGE analysis of ab103955
  • SDS PAGE analysis of ab103955
  • The Specific activity of ab103955 was determined to be 82 nmol/min/mg.
  • SDS-PAGE showing ab103955 at approximately 72kDa.

References

ab103955 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab103955.
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