Description

  • Product name

    Recombinant Human Caspase-2 protein (denatured)
    See all Caspase-2 proteins and peptides
  • Purity

    > 80 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MAGKEKLPKM RLPTRSDMIC GYACLKGTAA MRNTKRGSWY IEALAQVFSE RACDMHVADM LVKVNALIKD REGYAPGTEF HRCKEMSEYC STLCRHLYLF PGHPPT
    • Predicted molecular weight

      14 kDa including tags
    • Amino acids

      348 to 452
    • Tags

      His tag N-Terminus
    • Additional sequence information

      Protein corresponds to full length Caspase-2 subunit, p12 (NP_116764.)
  • Description

    Recombinant Human Caspase-2 protein

Specifications

Our Abpromise guarantee covers the use of ab180342 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8
    Constituents: 0.32% Tris HCl, 2.4% Urea, 10% Glycerol

General Info

  • Alternative names

    • CASP 2
    • CASP-2
    • Casp2
    • CASP2_HUMAN
    • Caspase 2
    • Caspase 2 apoptosis related cysteine peptidase
    • Caspase-2 subunit p12
    • Caspase2
    • ICH 1
    • ICH 1 protease
    • ICH 1L
    • ICH1
    • ICH1 protease
    • ICH1L
    • NEDD-2
    • NEDD2
    • Neural precursor cell expressed developmentally down-regulated protein 2
    • PPP1R57
    • Protease ICH-1
    • Protein phosphatase 1 regulatory subunit 57
    see all
  • Function

    Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
  • Tissue specificity

    Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
  • Sequence similarities

    Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • Post-translational
    modifications

    The mature protease can process its own propeptide, but not that of other caspases.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab180342 (3 μg).

References

ab180342 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab180342.
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